« January 2020 »




Professionell begleitete Hightech-Ausgründungen als Königsweg.

Dr. Wolfgang Jost, Niko Bausch, Prof. Dr. Bernhard Arnolds

Best Practice Technologietransfer Baden-Württemberg, Beispiele erfolgreicher Transfersysteme, BIOPRO Baden-Württemberg, 26-33

Low-Volume Label-Free Detection of Molecule-Protein Interactions on Microarrays by Imaging Reflectometric Interferometry

Juergen Burger, Christin Rath, Johannes Woehrle, Philipp A. Meyer, Nessim Ben Ammar, Normann Kilb, Thomas Brandstetter, Florian Pröll, Guenther Proll, Gerald Urban, and Guenter Roth

Journal of Laboratory Automation, DOI: 10.1177/2211068216657512

Semi-contact-writing of polymer molds for prototyping PDMS chips with low surface roughness, sharp edges and locally varying channel heights

L. Gutzweiler, F. Stumpf, L. Tanguy, G. Roth, P. Koltay, R. Zengerle, L. Riegger

2016 J Micromech Microeng, Band: 26, Nummer: 4, Seiten: 45018 – 45027: DOI: 10.1088/0960-1317/26/4/045018


A Peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction.

Witsenburg, J. J.; Sinzinger, M. D.; Stoevesandt, O.; Ruttekolk, I. R.; Roth, G.; Adjobo-Hermans, M. J. W.; Brock

Chembiochem; DOI 10.1002/cbic.201402622

Single-cell PCR of genomic DNA enabled by automated single-cell printing for cell isolation

F. Stumpf, J. Schoendube, A. Gross, C. Rath, S. Niekrawietz, P. Koltay, G. Roth;

Biosens Bioelectron; DOI 10.1016/j.bios.2015.03.008


Protein microarray generation by in situ protein expression from template DNA.

Kilb, N.; Burger, J.; Roth, G

Engineering in Life Sciences ; DOI 10.1002/elsc.201300052

Real-time PCR based detection of a panel of food-borne pathogens on a centrifugal microfluidic "LabDisk" with on-disk quality controls and standards for quantification.

Strohmeier, O.; Marquart, N.; Mark, D.; Roth, G.; Zengerle, R.; Stetten, F. v.

Analytical Methods; DOI 10.1039/C3AY41822G

Human Papillomavirus DNA and Host Gene mRNA Biomarker Detection in a "Micro Total Analysis System" (microTAS) Device to Aid Diagnosis of Cervical Intraepithelial Neoplasia.

Keegan H. and Roth, G. and many others et. al.


A Quantitative Assessment of Costimulation and Phosphatase Activity on Microclusters in Early T Cell Signaling.

Witsenburg, J.J.; Glauner, H. ; Muller, J.P.; Groenewoud, J.M.M.; Roth, G.; Bohmer, FD (Boehmer, Frank-Dietmar)[ 2 ] ; Adjobo-Hermans, M.J.W. ; Brock, R.

PLOS ONE; DOI 10.1371/journal.pone.0079277


Centrifugal gas-phase transition magnetophoresis (GTM)‐a generic method for automation of magnetic bead based assays on the centrifugal microfluidic platform and application to DNA purification.

Strohmeier, O.; Emperle, A.; Roth, G.; Mark, D.; Zengerle, Roland; Stetten, Felix von

Lab on a Chip; DOI 10.1039/c2lc40866j

Multiplex genotyping of KRAS point mutations in tumor cell DNA by allele-specific real-time PCR on a centrifugal microfluidic disk segment.

Strohmeier, O.; Laßmann, S.; Riedel, B.; Mark, D.; Roth, G.; Werner, M. et al.

Microchimica Acta; DOI 10.1007/s00604-013-1099-z

Bubble Jet agent release cartridge for chemical single cell stimulation.

Wangler, N.; Welsche, M.; Blazek, M.; Blessing, M.; Vervliet-Scheebaum, M.; Reski, R., Roth, G. et al.

Biomedical microdevices; DOI 10.1007/s10544-012-9681-4


Mediator probe PCR: a novel approach for detection of real-time PCR based on label-free primary probes and standardized secondary universal fluorogenic reporters.

Faltin, B.; Wadle, S.; Roth, G.; Zengerle, R.; Stetten, F. v.

Clinical chemistry; DOI 10.1373/clinchem.2012

Universal protocol for grafting PCR primers onto various lab-on-a-chip substrates for solid-phase PCR.

Hoffmann, J.; Hin, S.; Stetten, F. v.; Zengerle, R.; Roth, G.

RSC Advances; DOI 10.1039/C2RA01250B

Solid-phase PCR in a picowell array for immobilizing and arraying 100000 PCR products to a microscope slide.

Hoffmann, J.; Trotter, M.; Stetten, F. v.; Zengerle, R.; Roth, G.

Lab on a Chip; DOI 10.1039/c2lc40534b

Construction of a Microstructured Collagen Membrane Mimicking the Papillary Dermis Architecture and Guiding Keratinocyte Morphology and Gene Expression.

Lammers, G.; Roth, G.; Heck, M.; Zengerle, R.; Tjabringa, G. S.; Versteeg, E. M. et al.

Macromolecular bioscience; DOI 10.1002/mabi.201100443

Centrifugo-dynamic inward pumping of liquids on a centrifugal microfluidic platform.

Zehnle, S.; Schwemmer F.; Roth, G.; Stetten, F. v. et.al.

Lab on a Chip; DOI 10.1039/c2lc40942a

Nanotechnology-based biosensors and diagnostics: technology push versus industrial/healthcare requirements.

Vashist, S. K.; Venkatesh, A. G.; Mitsakakis, K.; Czilwik, G.; Roth, G.; Stetten, F. v.; Zengerle, R.

BioNanoScience; DOI 10.1007/s12668-012-0047-4


Controlled counter-flow motion of magnetic bead chains rolling along microchannels.

Karle, M.; Wöhrle, J.; Miwa, J.; Paust, N.; Roth, G.; Zengerle, R.; Stetten, F. v.

Microfluidics and Nanofluidics; DOI 10.1007/s10404-010-0727-8

Protein expression from exogenous mRNA: uptake by receptor-mediated endocytosis and trafficking via the lysosomal pathway.

Lorenz, C.; Fotin-Mleczek, M.; Roth, G.; Becker, C.; Dam, T. C.; Verdurmen, W. P. R. et al.

RNA biology; DOI 10.4161/rna.8.4.15394


Antineuronal antibodies in sporadic late-onset cerebellar ataxia.

Bürk, K.; Wick, M.; Roth, G.; Decker, P.; Voltz, R.

Journal of neurology; DOI 10.1007/s00415-009-5262-8

Microstructuring of polymer films for sensitive genotyping by real-time PCR on a centrifugal microfluidic platform.

Focke, M.; Stumpf, F.; Faltin, B.; Reith, P.; Bamarni, D.; Wadle, S., Roth, G.; et al.

Lab on a Chip; DOI 10.1039/c004954a

Centrifugal microfluidic system for primary amplification and secondary real-time PCR.

Focke, M.; Stumpf, F.; Roth, G.; Zengerle, R.; Stetten, F. v.

Lab on a Chip ; DOI 10.1039/c0lc00161a

Peptide microarrays for the profiling of cytotoxic T-lymphocyte activity using minimum numbers of cells.

Hoff, A.; Bagû, A.-C.; André, T.; Roth, G.; Wiesmüller, K.-H.; Gückel, B.; Brock, R.

Cancer Immunology, Immunotherapy ; DOI 10.1007/s00262-010-0867-4

Continuous microfluidic DNA extraction using phase-transfer magnetophoresis.

Karle, M.; Miwa, J.; Czilwik, G.; Auwärter, V.; Roth, G.; Zengerle, R.; Stetten, F.v.

Lab on a Chip ; DOI 10.1039/c0lc00129e

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation.

Leemhuis, J.; Bouché, E.; Frotscher, M.; Henle, F.; Hein, L.; Herz, J.; Roth, G.; et al.

The Journal of Neuroscience; DOI 10.1523/JNEUROSCI.4036-10.2010

Microfluidic lab-on-a-foil for nucleic acid analysis based on isothermal recombinase polymerase amplification (RPA).

Lutz, S.; Weber, P.; Focke, M.; Faltin, B.; Hoffmann, J.; Müller, C., Roth, G.; et al.

Lab on a Chip; DOI 10.1039/b921140c

Lab-on-a-chip solutions designed for being operated on standard laboratory instruments.

Mark, D.; Focke, M.; Lutz, S.; Burger, J.; Müller, M.; Riegger, L., Roth, G; et al.

Procedia Engineering; DOI 10.1016/j.proeng.2010.09.142

Microfluidic lab-on-a-chip platforms: requirements, characteristics and applications.

Mark, D.; Haeberle, S.; Roth, G.; Stetten, F. v.; Zengerle, R.

Chemical Society Reviews ; DOI 10.1039/B820557B


Physiologische Assays in einem DVD Player am Beispiel der Messung des Hämatokrit.

Burger, J.; Mark, D.; Roth, G.; Müller, C.; Zengerle, R.; Stetten, F. von; Park, Y.


Neurological symptoms in patients with biopsy proven celiac disease.

Bürk, K.; Farecki, M.-L.; Lamprecht, G.; Roth, G.; Decker, P.; Weller, M. et al.

Movement Disorders; DOI 10.1002/mds.22821

Natural Killer Cell Signal Integration Balances Synapse Symmetry and Migration.

Culley, F. J.; Johnson, M.; Evans, J. H.; Kumar, S.; Crilly, R.; Casasbuenas, J., Roth, G.; et al.

PLoS Biol; DOI 10.1371/journal.pbio.1000159

Diffusion-Driven Device for a High-Resolution Dose- Response Profiling of Combination Chemotherapy.

Ganser, A.; Roth, G.; van Galen, J. C; Hilderink, J.; Wammes, J. J. G.; MuĚller, I. et al.

ANALYTICAL CHEMISTRY ; DOI 10.1021/ac900415s

Mikrofluidik-Plattform zur kontinuierlichen Aufreinigung von Biomolekülen.

Karle, M.; Miwa, J.; Haeberle, S.; Roth, G.; Zengerle, R.; Stetten, F. von

Chemie Ingenieur Technik;

Kontinuierlich arbeitende Mikrofluidik-Plattform zur Aufreinigung von Biomolekülen.

Karle, M.; Miwa, J.; Roth, G.; Haeberle, S.; Zengerle, R.; Stetten, F. v.


Isothermal Polymerase Amplification in a Centrifugal Microfluidic Foil Cartridge.

Lutz, S.; Weber, P.; Focke, M.; Faltin, B.; Roth, G.; Piepenburg, O. et al.

Procedia Chemistry; DOI 10.1016/j.proche.2009.07.132

Lab-on-a-Chip Foundry Service: Schnelle kundenspezifische Implementierung miniaturisierter biochemischer Assays.

Metz, T.; Karle, M.; Preis, T.; Mark, D.; Roth, G.; Müller, C. et al.



Stimulus Dependence of the Action of Small-Molecule Inhibitors in the CD3/CD28 Signalling Network.

Köhler, K.; Ganser, A.; André, T.; Roth, G.; Grosse-Hovest, L.; Jung, G.; Brock, R.

ChemMedChem; DOI 10.1002/cmdc.200800134


Ubiquitin Binds to a Short Peptide Segment of Hydrolase UCH-L3: A Study by FCS, RIfS, ITC and NMR.

Roth, G.; Freund, S.; Möhrle, B.; Wöllner, K.; Brünjes, J.; Gauglitz, G. et al.



Diffusion along microfluidic channels.

Heeren, A.; Luo, C. P.; Roth, G.; Ganser, A.; Brock, R.; Wiesmüller, K-H et al.

Microelectronic Engineering; DOI 10.1016/j.mee.2006.01.187

Measuring biomolecular binding events with a compact disc player device.

Lange, S. A.; Roth, G.; Wittemann, S.; Lacoste, T.; Vetter, A.; Grässle, J. et al.

Angewandte Chemie; DOI 10.1002/ange.200501243


Microsystems for the analysis of cellular signal transduction.

Ganser, A.; Roth, G.; Köhler, K.; André, T.; Heeren, A.; Henschel, W. et al.

NanoBiotechnology; DOI 10.1007/s12030-005-0039-3


Center for Biological Systems Analysis

University of Freiburg


  • Address:

    Habsburgerstr. 49
    79104 Freiburg
  • Delivery entrance:

    Hauptstr. 1
    79104 Freiburg


Personal tools